Multifactorial
Multifactorial
Apr 11, 2025
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Multifactorial Inheritance
Multifactorial Inheritance
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•Cleft lip (± palate) is usually a multifactorial anomaly: genes environment, not a single cause. •Genetic factors: multifactorial inheritance with familial clustering; can be part of chromosomal/single‑gene syndromes such as trisomy 13. •Maternal conditions: poorly controlled pre‑gestational diabetes and advanced maternal age (via higher aneuploidy risk) increase the chance of clefting. • Medications/substances: first‑trimester exposure to some antiepileptics (e.g., valproate, topiramate) and m
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